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Levemir® FlexPen®

> Can be used by children as young as 2 years old with type 1 diabetes
> Is Pregnancy Category B
> Can be used in combination with a GLP-1 therapy and diabetes pill

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How Does Levemir® (insulin detemir [rDNA origin] injection) Work?

Levemir® (insulin detemir [rDNA origin] injection) is a long-acting insulin

Levemir® (insulin detemir [rDNA origin] injection) is used to treat both type 1 and type 2 diabetes. As an insulin therapy that helps control blood sugar levels between meals and while you sleep, Levemir® is a long-acting insulin.

In people without diabetes, long-acting insulin, or basal insulin is produced by the pancreas in a steady amount, day and night. This keeps blood sugar within a normal range overnight and between meals. With diabetes, your pancreas does not make enough insulin to control your blood sugar. As a long-acting insulin, Levemir® helps control your blood sugar for up to 24 hours.

Some people may take Levemir® by itself, while others may take Levemir® along with other diabetes medicines or with a fast-acting, or bolus insulin.

Levemir® (insulin detemir [rDNA origin] injection) in combination with other diabetes medicines

When you are first diagnosed with diabetes, your doctor may prescribe meal planning, exercise, and diabetes pills to help control your blood sugar levels. However, diabetes pills sometimes stop working after a few months or years. This may be due to the way diabetes pills work, or to your diabetes changing over time. When you need more control over your blood sugar levels, your doctor may recommend combination therapy with diabetes pills and Levemir®. Your doctor may also recommend a diabetes pill and GLP-1 therapy to use in combination with Levemir®.

Levemir® (insulin detemir [rDNA origin] injection) in combination with a fast-acting insulin

People who take Levemir® may also take a fast- or rapid-acting insulin. In people without diabetes, fast-acting insulin is released in quick bursts after a meal to cover the blood sugar that is produced when food is digested. Fast-acting and long-lasting insulins work together to control blood sugar.

Taking a long-acting insulin such as Levemir® and a fast-acting insulin is called "basal-bolus therapy." Basal-bolus therapy is useful for people with diabetes who need more control over their blood sugar levels.

Selected Important Safety Information

What are the possible side effects of Levemir®?

• Low blood sugar (hypoglycemia), including when too much is taken. Some symptoms include sweating, shakiness, confusion, and headache. Severe low blood sugar can cause unconsciousness, seizures, and death.

• Other side effects include injection site reactions (like redness, swelling, and itching), skin thickening or pits at the injection site, if taken with thiazolidinediones (TZDs) possible heart failure, and weight gain.

Please click here for additional Important Safety Information