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Levemir® FlexPen®

> Can be used by children as young as 2 years old with type 1 diabetes
> Is Pregnancy Category B
> Can be used in combination with a GLP-1 therapy and diabetes pill

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Glossary

A1C: A test that measures blood sugar, or glucose, levels for the previous 2-3 months.

Bad cholesterol: Low-density lipoprotein (LDL) cholesterol. A high level of bad cholesterol leads to a buildup of cholesterol in arteries and may lead to heart disease.

Basal insulin: See long-acting insulin.

Bolus insulin: Insulin that covers a rise in blood sugar, often related to a meal or snack. See fast- or rapid-acting insulin.

Cholesterol: A fat-like substance that is found in the bloodstream and body tissue. Cholesterol is used by the body to make hormones and build cell walls. However, too much cholesterol can cause a disease that harms blood circulation.

Dietitian: A health care professional who advises people about meal planning, weight control, and diabetes management.

Endocrinologist: A doctor who treats people who have endocrine gland problems such as diabetes.

Fast- or rapid-acting insulin: An insulin that starts working within 5 to 10 minutes and lasts up to 3 hours, depending on the type used.

Fasting blood glucose: The measurement of a person’s blood sugar when the person has not eaten in 8 to 12 hours.

Glucose: Also known as blood sugar, glucose is used by the body for fuel. Glucose is produced when the digestive system breaks down food.

Glucose tablets: Tablets made of pure glucose, used for treating low blood sugar.

Good cholesterol: High-density lipoprotein (HDL) cholesterol. Good cholesterol helps the liver remove all cholesterol from your body. The higher your good cholesterol level, the lower your chance of getting heart disease.

Hormone: A chemical made by the body to help it work in different ways. For example, insulin is a hormone made in the pancreas to help the body use glucose as energy.

Hyperglycemia: A condition people with diabetes may experience when their blood glucose levels are too high. Symptoms of hyperglycemia may include having to urinate often, being very thirsty, and losing weight.

Hypoglycemia: A condition that occurs when a person’s blood sugar is lower than normal, usually less than 70 mg/dL. Signs include hunger, nervousness, shakiness, perspiration, dizziness or light-headedness, sleepiness, and confusion. If left untreated, hypoglycemia may lead to unconsciousness. Hypoglycemia is treated by consuming a carbohydrate-rich food such as a sugar tablet or juice. It may also be treated with an injection of glucagon if the person is unconscious or unable to swallow.

Long-acting insulin: A type of insulin, such as Levemir® (insulin detemir [rDNA origin] injection), that lowers blood sugar throughout the day. Long-acting insulin covers blood glucose between meals and at nighttime. It tends to lower glucose levels fairly evenly over a 24-hour period.

Lipodystrophy: Small dents or lumps in the surface of the skin caused by repeated insulin injections in the same area.

Nephrologist: A medical professional involved with the health of the kidneys.

Nutritionist: A person with training in nutrition. A nutritionist may have specialized training and qualifications, but also may not.

NPH: An intermediate-acting insulin used to treat diabetes. It starts working more slowly, has a lower peak, and lasts longer than regular insulin. NPH stands for Neutral Protamine Hagadorn, so named because it has a neutral pH, contains protamine, and was invented by a scientist named Hans Christian Hagedorn.

Ophthalmologist: A medical doctor who diagnoses and treats all eye diseases and eye disorders.

Pancreas: An organ in the body that produces insulin, which enables the body to use glucose for energy.

Podiatrist: A doctor who specializes in the feet. Podiatrists also provide regular foot examinations and treatment.

Postprandial blood glucose: The measurement of a person’s blood sugar level 1 to 2 hours after the person has eaten, also known as post-meal blood glucose.

Prediabetes: A condition in which blood sugar levels (fasting plasma glucose) are higher than normal (100 mg/dL) but are not high enough for a diagnosis of diabetes (126 mg/dL). People with prediabetes are at increased risk for developing type 2 diabetes. Other names for prediabetes are impaired glucose tolerance and impaired fasting glucose.

Type 1 diabetes: A condition characterized by high blood sugar levels caused by a lack of insulin. Occurs when the body’s immune system attacks the insulin-producing beta cells in the pancreas and destroys them. The pancreas then produces little or no insulin and therefore blood sugar cannot enter the cells to be used for energy. Type 1 diabetes develops most often in young people but can appear in adults.

Type 2 diabetes: A condition characterized by high blood sugar levels that occur when the body does not make enough insulin, and cells may not use naturally available insulin correctly. Type 2 diabetes develops most often in middle-aged and older adults. Clinically based reports and regional studies suggest that type 2 diabetes, while still rare in children and adolescents, is being diagnosed more frequently in children and adolescents, particularly in American Indians, African Americans, and Hispanic/Latino American populations.

Selected Important Safety Information

What are the possible side effects of Levemir®?

• Low blood sugar (hypoglycemia), including when too much is taken. Some symptoms include sweating, shakiness, confusion, and headache. Severe low blood sugar can cause unconsciousness, seizures, and death.

• Other side effects include injection site reactions (like redness, swelling, and itching), skin thickening or pits at the injection site, if taken with thiazolidinediones (TZDs) possible heart failure, and weight gain.

Please click here for additional Important Safety Information